Real Madrid captain Sergio Ramos broke his nose in Saturday’s goalless La Liga draw with Atletico Madrid.
The European champions have not revealed a timeframe for the centre-back’s return.
Ramos, 31, was accidentally kicked in the face by Lucas Hernandez. He received treatment and played on, but was replaced at half-time.
“He couldn’t continue. We’ll have to see how long he’s out for,” said boss Zinedine Zidane.
Defending champions Real are 10 points behind leaders Barcelona following the draw at the Wanda Metropolitano.
Ramos tweeted: “I would bleed a thousand times for this badge and this shirt. Thanks for your support. I’ll be back in no time.”