Steven Finn has been ruled out of England’s Ashes tour after scans showed he has torn his left knee cartilage.
The pace bowler, 28, who was added to the squad following Ben Stokes’ arrest, was injured in training on Thursday.
He will return to the UK in the next 48 hours to meet with specialists and decide whether he requires surgery.
England say they will announce a replacement in due course. Their first Test against Australia begins in Brisbane on 23 November.
Before that, the tourists play two warm-up matches against a Cricket Australia XI, the first of which is on Wednesday.
Speaking to BBC Sport before the result of Finn’s scan was revealed, coach Trevor Bayliss had positive news about Moeen Ali’s fitness however.
Off-spinning all-rounder Moeen, 30, missed training on Friday with a side injury, but Bayliss said he “will be fine”.
He added Moeen would play the final warm-up next week in Townsville.
Mason Crane will again deputise for Moeen in Wednesday’s warm-up game, which will be a day-night match as England prepare for the floodlit Test at the Adelaide Oval next month.
Stuart Broad is rested with Jake Ball and Craig Overton given the chance to press their claims for an Ashes start.
Dawid Malan is preferred to Gary Ballance at five with James Vince continuing at three.